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KMID : 0370019970110000005
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Chung-Ang Journal of Pharmacal Sciences
1997 Volume.11 No. 0 p.5 ~ p.13
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Development of Intranasal Delivery System of Antifungal Agent Econazole Nitrate
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Abstract
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1:2 Ratio inclusion complexes of econazole(EC) with alpha cycloclextrin(αCD) and dimethyl-beta-cyclodextrin(DMβCD) were prepared by solvent evaporation method.
The dissolution rate of EC was significantly increased by the formation of inclusion complex at pH 4.0. The mean dissolution time(MDT. min) which represents the relative rapidity of dissolution rate was in the order EC-DMβCD inclusion complex (3.00min) > EC-αCD inclusion complex(7.22 min) > EC-αCD physical mixture > EC-DMβCD physical mixture(25.00min).
The intrinsic absorptivity of EC-CDs inclusion complexes in the jejunum and the nasal cavity were investigated simultaneously using the in situ nasal and jejunal perfusion method.
The rank order of apparent EC permeability (Papp : cm/sec × 10-5) corrected to surface area of absorption was 5.00±0.2(N. EC-DMβCD) > 3.12±0.1(N. EC-αCD) > 2.71±0.2(J. EC-DMβCD) > 2.41±0.31(J. EC-αCD) at pH 4.0
The present results suggest that EC-DMBCD inclusion complex may serve as a potential mean for the nasal delivery system of econazole.
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